3:00 p.m.
Department of Chemistry and Biochemistry Organic/Inorganic/Materials Seminar Series
Professor Edith C. Glazer, North Carolina State University Hosted by Teresa Rapp
Targeting Cytochrome P450s - From Biophysics to Selective Inhibitors and Photons
Cytochrome P450s (CYPs) are a superfamily of enzymes that perform challenging reactions in all life forms. In humans, these amazing enzymes are responsible for the metabolism of xenobiotics, as well as the biosynthesis of several essential signaling molecules. Thus, CYPs play an integral protective role via degradation, in addition to aiding in the regulation of growth, development, and homeostasis via (bio)synthesis. Notably, these two processes have opposite requirements for selectivity, with the drug metabolizing CYP enzymes of the liver exhibiting extreme promiscuity while the biosynthetic CPYs of other tissues performing chemistry with exquisite regio- and stereo-control. We are working towards an understanding of P450 structural flexibility and dynamics that can be exploited for the development of drugs selective for specific P450 enzymes that play a role in cancer initiation, progression, and resistance to treatment. Our current focus is on CYP1B1, which is absent or expressed at very low levels in the liver and healthy tissues while being overexpressed in tumors, giving it the title of “universal tumor antigen”. Evidence from basic science, clinical, and epidemiological studies demonstrate that CYP1B1 creates DNA mutagens, facilitates malignant progression, and then causes resistance to the majority of common chemotherapeutics, regardless of their mechanism of action. I will detail our development of cell-based assays for CYP1B1 and related family members, and will present our approach to the development of highly potent and selective CYP1B1 inhibitors, including agents that can be activated with light.
This work was supported by the National Institutes of Health (R01 138882)
10:00 a.m.
Please join us Tuesday mornings for a free cup of coffee, pastries, and conversation with your history department community! We’re excited to continue this tradition for our history undergraduate and graduate students, faculty, and staff. We hope to see you there!
4:00–5:30 p.m.
Join Ms. Ilana Sol, documentary filmmaker and archival producer, for a special screening of her film Samurai in the Oregon Sky.
Following the screening, Ms. Sol will discuss the inspiration behind the film, the research process, and the stories uncovered along the way. She will also take questions from the audience.
Samurai in the Oregon Sky is a compassionate and engaging film that tells the story of Fujita Nobuo, the only Japanese pilot to bomb the US mainland during World War II, and the connections he formed with Brookings, Oregon, the site of his attack.
11:00 a.m.–2:00 p.m.
Want to learn more about graduate school or different types of part-time/full-time jobs, internships, volunteer opportunities, and careers in the health professions? The Health Grad & Career Expo is your chance to get curious about your present and future in healthcare! This expo is a mix of graduate schools, health-related businesses, non-profits, and government agencies excited to share more with you about their organization/program and early career talent and educational opportunities. Great for students exploring career paths as well as students ready to start applying for the year ahead.
Register on Handshake today to learn about all the schools and organizations coming, positions of interest, and get tips and advice for how to make the most of the expo.
For more information, visit the Unviersity Career Center in Tykeson-Garden Level to learn more about how the UCC supports students applying to grad school through career coaching and document reviews! Also check out our NEW online career exploration resources around Health & Scientific Discovery!
4:00 p.m.
This lecture will examine narrative constructions used in contemporary German and African literature to frame intercultural awareness by promoting an openness to pluralism and respect for differences. It will critically analyze how authors respond to issues of power dynamics and cultural impacts stemming from colonial history. In the first step of the argumentation, I will explore the concept of aesthetics or Poetizität’ as explained by Aimé Césaire, Georg Lukács, Paul Ricoeur and Umberto Eco. Then, I will analyze how literary texts deconstruct colonial strategies of power, construct hybrid identities by discussing notions of home or belonging, and frame a politics of similarity that engages reciprocity, transfer processes between North and South. I will argue that one of the specific relevance of this intercultural texts is to let the reader gain an aesthetic experience (ästhetische Erfahrung) and a shared history between human beings.
5:30–7:00 p.m.
As the Trump administration hits its 100-day mark, UO faculty from History, Law, and Political Science help make sense of the headlines and place today’s events in historical context. Pizza will be served.
DEPORTATION: Wednesday, April 23, 2025 AUTHORITARIANISM: Wednesday, April 30, 2025 ANTI-ENVIRONMENTALISM: Wednesday, May 14, 2025
All events held from 5:30 pm to 7:00 pm in McKenzie Hall 375. Free and open to the public
noon
Click to Download PDF of Poster
The Limits and Possibilities of Cross-border Latinidades & Indigeneities April 24 / 12pm-5pm / Ford Lecture Hall, JSMA
The Limits and Possibilities of Cross-border Latinidades & Indigeneities symposium will bring together interdisciplinary Latinx and Indigenous scholars and researchers studying settler colonialism, transnational Indigeneities, and race through archival and ethnographic approaches. The conference will explore the boundaries between Indigeneity and Latinidad, both historically and in the present. It examines shifting borders and interactions of Indigenous and Latine people and diasporas, focusing on regions that are now California, Texas, Oregon, Mexico, and Central America.
12pm-1pm: Conference Opening and Keynote Presenters: María Josefina Saldaña-Portillo (New York University); Moderated by Chris Chavez (SOJC, University of Oregon); Special remarks by Jason Younker, Assistant Vice President, Advisor to the President on Sovereignty and Government-to-Government Relations, Chief, Coquille Tribe
1pm-2pm: Pre-1848 Mexican Borderlands: Californio Ranchero Culture and Indigenous California Presenters: Yvette Saavedra (Women's, Gender, and Sexuality Studies, University of Oregon) and Naomi Sussman (History, University of Oregon); Moderated by Laura Pulido (Indigenous, Race, and Ethnic Studies, University of Oregon)
2pm-3pm: Media, History and Citizenship of Indigenous and Latinx Peoples: Contested Lands and Identities across the Borderlands Presenters: Ramón Resendiz (Indiana University, UO Anthropology) and Rachel Nez (Navajo Diné Nation, Fort Lewis College); Moderated by Gabe Sanchez (Anthropology, University of Oregon)
3pm-4pm: Building Comunidad and Transborder Territories in Indigenous Diasporas From Mexico and Guatemala Presenters: Daina Sanchez (UC Santa Barbara) and Lynn Stephen (Anthropology, University of Oregon); Moderated by Jason Younker (University of Oregon)
4pm-5pm: Closing Remarks and Conversation Closing remarks from Miguel Gualdrón Ramírez (Philosophy, University of Oregon) and María Josefina Saldaña-Portillo (New York University)
5pm-6pm: Post-conference Reception Mingle with presenters and enjoy complimentary food and refreshments. All are welcome!
Questions? Email cllas@uoregon.edu
3:30–5:30 p.m.
The 2025 China Town Hall program will discuss President Trump’s China policy 100 days in, with featured speakers Ryan Hass, Director of John L. Thorton China Center at the Brookings Institution; Matthew Turpin, Visiting Fellow at the Hoover Institution; and Lingling Wei, Chief China Correspondent at The Wall Street Journal.
The University of Oregon's local discussion will be led by Daniel Buck, Associate Professor of Geography at the University of Oregon, who is currently teaching ASIA 480: Chinese Economy in spring, 2025.
The event is hosted by the Center for Asian and Pacific Studies at the University of Oregon.
6:00–7:30 p.m.
Will Jones, professor of history at the University of Minnesota, will deliver the Bob Bussel Labor History Lecture on April 24, 2025.
The UO Labor Education and Research Center (LERC) created the lecture in recognition of Bob Bussel’s years of service as LERC’s director and an affiliated member of the UO history department. The lecture features historians with a distinguished record of scholarship, a commitment to public history, and an interest in labor and working-class issues. Will Jones is a professor of history at the University of Minnesota with a particular interest in issues of race and class. Professor Jones is the author of two books and numerous articles on labor and working-class history. He is also a past president of the Labor and Working-Class History Association.
6:00–10:00 p.m.
The Women’s Center is beyond excited to invite you to our annual Take Back the Night Rally, March and Speak-Out Against Sexual and Domestic Violence.
Take Back the Night is on Thursday, April 24, starting with the rally at 6:00pm followed by the march at 7:00pm and student-led speak-out at 8pm.
The rally begins in the EMU Amphitheater at 13th Ave. and University St. followed by an approximately 1.6 mile march from the UO campus through the streets of Eugene and back to UO campus in the EMU Cedar and Spruce Rooms where the student-led speak out (by and for students) is held.
The UO Women’s Center holds this event in collaboration with the UO Campus Community (UO Muxeres, UOIWMGW, Prevention SVPE,UO Green and Yellow Garter Band and more).
Community collaborators will be on hand from 5:00 pm to 6:00 pm at tables surrounding the rally area.
Take Back the Night Rally, March and Speak-Out Against Sexual and Domestic Violence is an event for the entire University of Oregon campus community. Take Back the Night is a yearly international protest founded in 1976 which seeks to raise awareness about the realities of sexual and domestic violence on campus and in the community, both for survivors of sexual and domestic violence and those who want to support and bear witness in solidarity. Take Back the Night is a survivor-centered event that begins with a rally in the EMU Amphitheater, continues as a march through the streets of Eugene to symbolize reclaiming people’s safety on public streets at night, and ends with a student-led speak-out on campus during which survivors and allies can share personal stories of how sexual and domestic violence has impacted their lives.
The rally will feature UO student speakers from diverse intersecting identities and lived experiences, including the Native American community, Latine community, LGBTQIA2S+ community, a child abuse prevention advocacy organization and more.
Our theme for this year’s event is REST IS RESISTANCE, inspired by the work of Black activist Tricia Hersey. As well, we will continue to center marginalized communities too often left out of essential dialogue about sexual and domestic violence - despite being disproportionately impacted by these systems of oppression. As always, the Women’s Center is committed to providing this essential event to support survivors, educate the community and prevent future harm.
ASL interpretation will be provided at the rally. This event is wheelchair accessible and will have transportation available during the march and back to student-led speak-out. We ask that no UO professional staff or media be present during the student-led speak-out portion of the event to provide a sacred space for students to have dialogue circles of peer-to-peer support.
Event will take place **rain or shine** and is free and open to the public. We support and believe survivors in ALL WEATHER! Masks are not required but highly encouraged. Questions regarding Take Back the Night should be directed to:
UO Women’s Center Program Assistant, Karyn Schultz (karyns@uoregon.edu) UO Women's Center Leadership Fellow, alejandra pedraza (apedraza@uoregon.edu) UO Women’s Center Sexual Violence Prevention & Education Student Coordinator, Lola Sponaas (svpewc@uoregon.edu)